English In human pre-term labour, atosiban at the recommended dosage antagonises uterine contractions and induces uterine quiescence . Feature Flags: { msoloff @ … Carvajal, Jorge A. Did You Know? Using the mouse as our model system, we examined, by Western blot analysis, levels of active caspase 3 and its association with the degradation of uterine contractile proteins during pregnancy. The length of mammalian pregnancy is tightly regulated to assure the delivery of a newborn mature enough to survive the extra-uterine environment. translation and definition "quiescence", English-Greek Dictionary online. Additional filters were used downstream of clustering for genes related to uterine quiescence and term activation. Weiner, Carl P. Poblete, Jose A. Myometrial smooth muscle contractions are phasic in nature and are driven by action potentials. Feature Flags: { Close this message to accept cookies or find out how to manage your cookie settings. The safety and analysis populations were defined as all … 2013. These include the possibility of electrophysiological changes in myometrial cells. "newCiteModal": false Cuello, Mauricio A. "figures": false, PARTURITION is defined as the process of bringing forth of young which comprises of multiple transformations in both uterine and cervical functions There are four phases : Quiescence } "lang": "en" uterine quiescence and days to delivery. Delpiano, Ana M. Regulation of quiescence and contractility of the pregnant myometrium Preterm birth (6 births globally each year, is a major cause of death within the first month of postnatal life. Found 10 sentences matching phrase "quiescence".Found in 3 ms. Close this message to accept cookies or find out how to manage your cookie settings. During pregnancy, uterine quiescence is maintained by increased progesterone receptor (PR) activity, but labor is facilitated by a series of events that impair PR function. and and Render date: 2021-01-24T12:51:34.709Z Cuello, Mauricio A. Throughout most of pregnancy, uterine quiescence is maintained by increased progesterone receptor (PR) transcriptional activity, whereas spontaneous labor is initiated/facilitated by a concerted series of biochemical events that activate inflammatory pathways and have a … This data will be updated every 24 hours. At present, the exact factors initiating human parturition remain unknown, and labour may occur due to a loss of uterine quiescence, an increase in uterine contractility, or a combination of both. "openAccess": "0", In this study, we tested the central hypothesis that progesterone maintains uterine quiescence through regulation of active uterine caspase 3. Synonym Discussion of quiescent. Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland Baltimore, School of Medicine, Baltimore, Maryland. Ponce-Monter, Héctor uterine quiescence and days to delivery. quiescence . Published online by Cambridge University Press:  A. Oxytocin inhibits contraction of uterine smooth muscle 2019 Jan;39:520-530. doi: 10.1016/j.ebiom.2018.11.038. A successful pregnancy requires near complete relaxation of the uterus for more than ninety-five percent of gestation, overcoming the inherent tendency of the myometrium to contract with stretch. At the molecular level, an integrated uterine endoplasmic reticulum stress-unfolded protein response (UPR-ERSR) regulates both caspase-3 (CASP3) and caspase-7 (CASP7), preserving myometrial quiescence throughout gestation. Learn more. "isLogged": "0", The Evidence from human and animal studies indicates nitric oxide inhibits uterine contractility and may help maintain uterine quiescence during pregnancy. Arias-Montaño, José-Antonio Evidence from human and animal studies indicates nitric oxide inhibits uterine contractility and may help maintain uterine quiescence during pregnancy. The planned sample size (n=64) provided at least 86% power to detect a 40% absolute difference, or RR of 2.6, in the proportion of women achieving uterine quiescence. In this situation, measurement of cervical length during quiescence and during a uterine contraction is useful for differentiating a normal latent phase from dysfunctional active labor. Epub 2018 Nov 28. In contrast, UC frequency remained elevated (at 60% end-follicular phase values) until 4 days after hCG and declined thereafter (6 days after hCG). In this study, we identified a unique role for miR … Total loading time: 0.195 Author information: (1)Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX 77555, USA. A successful pregnancy requires near complete relaxation of the uterus for more than ninety-five percent of gestation, overcoming the inherent tendency of the myometrium to contract with stretch. The maintenance of uterine quiescence across gestation is fundamental for term parturition. As a result, forceful uterine contractions do not occur until the ninth month of pregnancy. "lang": "en" This active and highly regulated process is called myometrial quiescence. Soloff MS(1), Jeng YJ, Izban MG, Sinha M, Luxon BA, Stamnes SJ, England SK. "hasAccess": "0", Using the mouse as our model system, we examined, by Western blot analysis, levels of active caspase 3 and its association with the degradation of uterine contractile proteins during pregnancy. Soria-Jasso, Luis Araya, Francisca Isabel quiescence translation in English-Swedish dictionary. "metricsAbstractViews": false, Cells may exit the cell cycle at G 1 and enter a nonproliferative phase called G 0 or quiescence. Jofré, Nicolás M. 2016. 2013. and translation and definition "quiescence", English-Greek Dictionary online. Santiago, Chile. "hasAccess": "0", Hostname: page-component-76cb886bbf-kdwz2 It is accepted that whilst hormones such as oxytocin, vasopressin and prostaglandin F2α induce myometrial contractions, essentially via an elevation of intracellular calcium, other ligands, such as β-adrenoceptor agonists, calcitonin gene-related peptide, and prostaglandin E2, promote uterine quiescence via their ability to increase intracellular cyclic AMP levels. "shouldUseHypothesis": true, } In this study, we uncovered a previously undescribed regulatory pathway whereby … "shouldUseShareProductTool": true, In fertile women, directed unilateral transport of immotile sperm-like material through the genital tract to the side bearing the dominant follicle can be assessed using hysterosalping… In human pre-term labour, atosiban at the recommended dosage antagonises uterine contractions and induces uterine quiescence. The regulation of uterine activity during pregnancy can be divided into four distinct physiologic phases : Phase 0: inhibitors active – Throughout most of pregnancy the uterus is maintained in a state of functional quiescence through the action of various putative inhibitors including, but not limited to: The first phase is quiescence and represents that time in utero before labor begins when uterine activity is suppressed by the action of progesterone, prostacyclin, relaxin, nitric oxide, The periodical return of the symptoms after a shorter or longer period of quiescence. Showing page 1. The causes of preterm labor are not well understood, so progesterone action on the myometrium can provide clues about the processes that … PARTURITION is defined as the process of bringing forth of young which comprises of multiple transformations in both uterine and cervical functions There are four phases : Quiescence Get access to the full version of this content by using one of the access options below. What explains the quiescence of uterine smooth muscle during gestation? "figures": false, Vargas, Paula A. What explains the quiescence of uterine smooth muscle during gestation? If you should have access and can't see this content please. In human pre-term labour, atosiban at the recommended dosage antagonises uterine contractions and induces uterine quiescence. Hostname: page-component-76cb886bbf-pdn9z 2. Full text views reflects PDF downloads, PDFs sent to Google Drive, Dropbox and Kindle and HTML full text views. "shouldUseShareProductTool": true, In this study, we tested the central hypothesis that progesterone maintains uterine quiescence through regulation of active uterine caspase 3. quiescence . A.Le retour périodique des symptômes après un intervalle plus ou moins long de tranquillité. and 31 July 2001. "isUnsiloEnabled": true, School of Medicine, Pontificia Universidad Católica de Chile. Adequate uterine contractility is involved in the transport of the semen and gametes and in successful embryo implantation, whereas inadequate uterine contractility may lead to ectopic pregnancies, miscarriages, retrograde bleeding and endometriosis (Leyendecker et al., 2004; Bulletti and de Ziegler, 2005; Kissler et al., 2005). 2009. Furthermore, by means of immunoblotting and immunocytochemistry, we have demonstrated the expression of these isoforms as membrane-associated AC proteins, and identified changes in individual AC isoform expression during gestation. It is also clinically important to differentiate false labor 14 , 15 from uterine dysfunction in the latent phase, because their treatments differ. View all Google Scholar citations "openAccess": "0", We use cookies to distinguish you from other users and to provide you with a better experience on our websites. The regulation of uterine activity during pregnancy can be divided into four distinct physiologic phases : Phase 0: inhibitors active – Throughout most of pregnancy the uterus is maintained in a state of functional quiescence through the action of various putative inhibitors including, but not limited to: Bethune was a man of peace, one who wanted stability and who in the interests … Weiner, Carl P. Sobrevia, Luis A. Whilst many studies have aimed to understand the mechanisms underlying uterine contractility there is a relative paucity of data regarding myometrial relaxation. Additional filters were used downstream of clustering for genes related to uterine quiescence and term activation. "isLogged": "0", Barragán-Ramírez, Guillermo for this article. At present, the exact factors initiating human parturition remain unknown, and labour may occur due to a loss of uterine quiescence, an increase in uterine contractility, or a combination of both. Vidal, Rossana J. Carvajal, Jorge A. In this study, we tested the central hypothesis that progesterone maintains uterine quiescence through regulation of active uterine caspase 3. Query parameters: { Total loading time: 1.54 Previously, we discovered that miR-200 family members serve as progesterone (P4)-modulated activators of contraction-associated genes in the pregnant uterus. Poblete, José A. Full text views reflects PDF downloads, PDFs sent to Google Drive, Dropbox and Kindle and HTML full text views. This active and highly regulated process is called myometrial quiescence. labor are unique. Carvajal, Jorge A. This data will be updated every 24 hours. For clusters related to quiescence and term activation, a change of more than 20% was required for the midgestation (14.5 days) and term (18.5 days) time points, respectively, versus non-pregnant controls. These findings illustrate the diversity of potential cAMP generating pathways in human myometrium, and the complexity of the signal transduction systems underlying uterine quiescence. It requires not only the near absence of myometrial contractions, but also its refractoriness to contractile agents. The planned sample size (n=64) provided at least 86% power to detect a 40% absolute difference, or RR of 2.6, in the proportion of women achieving uterine quiescence. How to use quiescent in a sentence. During pregnancy, the uterine smooth muscle is quiescent. Quiescence search, in game tree searching (adversarial search) in artificial intelligence, a quiescent state is one in which a game is considered stable and unlikely to change drastically the next few plays Seed dormancy, a form of delayed seed germination Quiescent phase, … The safety and analysis populations were defined as all … Context sentences for "quiescence" in Polish These sentences come from external sources and may not be accurate. and The uterus (from Latin "uterus", plural uteri) or womb (/ w uː m /) is a major female hormone-responsive secondary sex organ of the reproductive system in humans and most other mammals.In the human, the lower end of the uterus, the cervix, opens into the vagina, while the upper end, the fundus, is connected to the fallopian tubes.It is within the uterus that the fetus develops during gestation. : The early Cretaceous is characterized by relative quiescence and thermal subsidence following late Jurassic rifting. Delpiano, Ana M. Ortiz, Mario Poblete, Jose A. Casanello, Paola C. "isUnsiloEnabled": true, The highest rates of preterm birth (≥15% of all live births) occur in sub-Saharan Africa, Pakistan and Indonesia. Mayén-García, Cynthia Delpiano, Ana María and relative uterine quiescence during continuing pregnancy to the initiation of uterine contractions at the onset of labour. If you should have access and can't see this content please. The four phases of labor from quiescence to involution are outlined in Figure 13-1. Quiescence (/kwiˈɛsəns/) is a state of quietness or inactivity. Ferrer, Fernando Andrés "newCiteModal": false In the menstrual cycle, a prompt decrease in UC frequency was observed. Estrogen receptor alpha isoform ERdelta7 in myometrium modulates uterine quiescence during pregnancy EBioMedicine. Fernández-Martínez, Eduardo Experimental Physiology (2001) 86.2, 265-272. Throughout most of pregnancy, uterine quiescence is maintained by increased progesterone receptor (PR) transcriptional activity, whereas spontaneous labor is initiated/facilitated by a concerted series of biochemical events that activate inflammatory pathways and have a negative impact on PR function. An important action of progesterone during pregnancy is to maintain the uterus in a quiescent state and thereby prevent preterm labor. Quiescent definition is - marked by inactivity or repose : tranquilly at rest. Published online by Cambridge University Press:  At present, the exact factors initiating human parturition remain unknown, and labour may occur due to a loss of uterine quiescence, an increase in uterine contractility, or a combination of both. During pregnancy, the uterine smooth muscle is quiescent. }, Uterine quiescence: the role of cyclic AMP, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK. uterine definition: 1. relating to the uterus: 2. relating to the uterus: 3. of or relating to the uterus: . : The next four decades saw periods of resurgence and quiescence in Soviet anti-Semitism. For clusters related to quiescence and term activation, a change of more than 20% was required for the midgestation (14.5 days) and term (18.5 days) time points, respectively, versus non-pregnant controls. Delpiano, Ana M. https://doi.org/10.1017/S0965539503001098. Get access to the full version of this content by using one of the access options below. Inactive, resting, silent Medtalk A period during which an infection is present but not active in a host Examples TB; chickenpox and recrudescence as herpes zoster–shingles. Using the mouse as our model system, we examined, … 2006. Cuello, Mauricio A. The appropriate timing of the onset of labor is critical to a successful pregnancy, with potentially devastating consequences resulting to both the mother and child with the onset of preterm labor. MECHANISMS UNDERLYING MYOMETRIAL QUIESCENCE DURING... Department of Obstetrics and Gynecology; Maternal-Fetal Research Laboratory. bab.la is not responsible for their content. Carvajal, Jorge Andrés "metricsAbstractViews": false, Rapture was self-transcending, which led … for this article. Whether a decrease in plasma progesterone is the essential prerequisite for the initiation of parturition or whether other factors also maintain uterine quiescence until delivery is not known. The maintenance of uterine quiescence across gestation is fundamental for term parturition. "shouldUseHypothesis": true, Cuello, Mauricio A. Carvajal, Jorge A. As a result, forceful uterine contractions do not occur until the ninth month of pregnancy. View all Google Scholar citations Query parameters: { }. Poblete, José A. Render date: 2021-01-22T15:18:36.920Z Effects of progesterone treatment on expression of genes involved in uterine quiescence. At the molecular level, an integrated uterine endoplasmic reticulum stress-unfolded protein response (UPR-ERSR) regulates both caspase-3 (CASP3) and caspase-7 (CASP7), preserving myometrial quiescence throughout gestation. * Views captured on Cambridge Core between September 2016 - 24th January 2021. We use cookies to distinguish you from other users and to provide you with a better experience on our websites. 2017. Maximal uterine quiescence was reached as early as 4 days after the LH surge (P<.05). 16 October 2003. Address for correspondence: Jorge A Carvajal, Marcoleta 391, Centro de Investigaciones Médicas, Pontificia Universidad Católica de Chile, Santiago, Chile. * Views captured on Cambridge Core between September 2016 - 22nd January 2021. We have verified the presence of mRNA encoding adenylyl cyclase (AC) isoforms I, II, III, V, VI, VII, VIII and IX in both non-pregnant and pregnant human myometrium, and in isolated myometrial cells maintained in cell culture. Of this content please a better experience on our websites Izban MG Sinha., school of Medicine, Baltimore, school of Medicine, Baltimore, Maryland and enter a nonproliferative called. Maintenance of uterine smooth muscle during gestation because their treatments differ cycle G! The quiescence of uterine smooth muscle during gestation 24th January 2021 latent phase, because their treatments.... Also its refractoriness to contractile agents prompt decrease in UC frequency was.... 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P4 ) -modulated activators of contraction-associated genes in the latent phase, because their treatments differ days.: 16 October 2003 as all … quiescence translation in English-Swedish Dictionary myometrium... `` quiescence ''.Found in 3 ms at G 1 and enter a nonproliferative phase called G 0 or.... By Cambridge University Press: 16 October 2003, Cynthia 2016 to provide you with better... To the uterus: caspase 3 contraction of uterine smooth muscle contractions are phasic in and!, Mario Arias-Montaño, José-Antonio Barragán-Ramírez, Guillermo and Mayén-García, Cynthia 2016 translation in English-Swedish Dictionary: October! Use cookies to distinguish you from other users and to provide you with a better experience on websites. Safety and analysis populations were defined as all … Effects of progesterone treatment on expression of genes involved uterine. Options below contractions do not occur until the ninth month of pregnancy: 16 October....