200 William Pitt Way . CAS# Chemical Name: Percent. Do not autoclave. 404.42 Melting point. Pittsburgh, PA 15238 . It is useful as a pH indicator with color changes with pH 0.2 - pH 1.8 and pH 7.1 - 8.8. EC Number 217-064-2. Ph Eur Synonym: Cresol red, o-Cresolsulfonphthalein CAS Number 1733-12-6. A solution is yellow when both methyl yellow and cresol purple are added. Cresol Red Revision Date 18-Jan-2018 Cresol red 1733-12-6 100 4. Applications. Cresol Red sodium salt. Depending on the temperature, cresols can be solid or liquid because they have melting points not far from room temperature. Beilstein/REAXYS Number 343399 . 1. Cresol Red does not inhibit Taq polymerase. PubChem Substance ID 24847173 Buy Cresol red sodium salt (CAS 62625-29-0), a pH indicator with color changes with pH 0.2 - pH 1.8 and pH 7.1 - 8.8, from Santa Cruz. The rest is produced by hydrolysis of chlorotoluenes or the related sulfonates. Cresols have an odor characteristic to that of other simple phenols, reminiscent to some of a "coal tar" smell. Cresol Red does not inhibit Taq polymerase to the same degree as other common loading dyes. Cresol red (full name: o-cresolsulfonephthalein) is a triarylmethane dye frequently used for monitoring the pH in aquaria. Subject:* missing translation for 'pleaseEnterSubject'. The top layer is a solution of phenol in water, and the bottom one a solution of water in phenol. solubility H 2 O: 1 mg/mL λ max 425 nm Featured Industry Diagnostic Assay Manufacturing storage temp. 9. In a 1% agarose gel, it runs approximately at the size of a 125 base pair (bp) DNA molecule (it depends on the concentration of buffer and other component). InChI=1S/C21H18O5S/c1-13-11-15(7-9-18(13)22)21(16-8-10-19(23)14(2)12-16)17-5-3-4-6-20(17)27(24,25)26-21/h3-12,22-23H,1-2H3, InChI=1/C21H18O5S/c1-13-11-15(7-9-18(13)22)21(16-8-10-19(23)14(2)12-16)17-5-3-4-6-20(17)27(24,25)26-21/h3-12,22-23H,1-2H3, Cc1cc(ccc1O)/C(=C/2C=CC(=O)C(=C2)C)c3ccccc3OS(O)=O, Except where otherwise noted, data are given for materials in their, Learn how and when to remove this template message, Cresol Red at OpenWetWare life scientists' wiki, https://en.wikipedia.org/w/index.php?title=Cresol_Red&oldid=966465054, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Articles lacking sources from September 2007, Creative Commons Attribution-ShareAlike License, This page was last edited on 7 July 2020, at 08:15. Solubility. Disposal considerations Waste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. 0. This is effective almost on all the microbes. View information & documentation regarding Cresol red, including CAS, MSDS & more. P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362, P403+233, P405, P501: NFPA 704 (fire diamond) 0. Like other types of phenols, they are slowly oxidized by long exposure to air, and the impurities often give samples of cresols a yellowish to brownis… Give a pH range for this solution. C and T manufactures Cresol and Soap solution according to bp1968 standards. Company Phone Number: (412) 826-5230 . Cresol red is a member of the class of 2,1-benzoxathioles that is 2,1-benzoxathiole 1,1-dioxide in which both of the hydrogens at position 3 have been substituted by 4-hydroxy-5-methylphenyl groups. Other solubilities: soluble in dil. 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 12/23/2014 Version: 1.0 12/23/2014 EN (English US) Page 1 SECTION 1: Identification of the substance/mixture and of the company/undertaking . No human or animal studies have shown harmful effects from cresols on reproduction. Its solubility is 0.77 grams per liter (g/l) in water and 2.9 g/l in ethanol . P-Cresol | CH3C6H4OH or C7H8O | CID 2879 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. C 21 H 18 O 5 S. Storage instructions. Company Phone Number: (412) 826-5230 . 4,4'-(1,1-Dioxido-3H-2,1 -benzoxathiol-3-ylidene)bis[2-methylphenol] Molecular weight. It has a role as an acid-base indicator, a dye and a two-colour indicator. Further, it plays an important role in molecular biology reactions in place of other loading dyes. soln. 7732-18-5 >99 ; Water . room temp SMILES string [Na+].Cc1cc(ccc1O)\C(=C2/ C=CC(=O)C(C)=C2)c3ccccc3S ([O-])(=O)=O … Get medical attention. Molecular Weight 382.43 . Soluble in water (slightly at 20°C), 50% ethanol (0.1%), dil. Cresol Red, 0.04 Percent (w/v) Aqueous Solution, also known as o-Cresolsulfonephthalein, is a triarylmethane dye. Depending on the temperature, cresols can be solid or liquid because they have melting points not far from room temperature. Empirical Formula (Hill Notation) C 21 H 18 O 5 S . alkalies and ethanol,, insoluble in diethyl ether, benzene: Visual Transition Interval: from pH 7.0 (orange) to pH 8.8 (purple) Color: Brown-Red or Green : SDS. 011-703-527-3887 . [9], Group of chemical compounds, types of methylphenol. Cresol And Soap Solution (B: P: 1968) This has a typical odor of chemical cresol. Bromophenol blue and xylene cyanol can also be used for this purpose. Product identifier . Cresol red indicator grade, Dye content 95 % Synonym: o-Cresolsulfonphthalein CAS Number 1733-12-6. Occupational Safety and Health Administration, National Institute for Occupational Safety and Health, "Making carbon nanotubes as usable as common plastics: Researchers discover that cresols disperse carbon nanotubes at unprecedentedly high concentrations", "Additive-free carbon nanotube dispersions, pastes, gels, and doughs in cresols", Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs) - Cresol (o, m, p isomers), https://en.wikipedia.org/w/index.php?title=Cresol&oldid=984355000, Short description is different from Wikidata, Articles with unsourced statements from December 2017, Creative Commons Attribution-ShareAlike License, mixture of cresols (tricresol): [1319-77-3], This page was last edited on 19 October 2020, at 17:50. Another method entails methylation of phenol with methanol over a solid acid catalyst, often comprising magnesium oxide or alumina. Contributors. [5][6], Cresols are precursors or synthetic intermediates to other compounds and materials, including plastics, pesticides, pharmaceuticals, and dyes. 1733-12-6 . CHEMTREC Phone Number: (800) 424-9300 or . soln. Cresol red solution 0.04 wt. 77, No. 200 William Pitt Way . acids, and dil. Cresol Red – Thymol Blue, Aqueous . Breathing high levels of cresols for a short time results in irritation of the nose and throat. COVID-19 is an emerging, rapidly evolving situation. Molecular Weight 382.43 . Company Identification: LabChem Inc . ca 250° dec. Solubility: Solubility in water: Soluble: Visual Transition Interval: from pH 7.0 (yellow) to pH 8.8 (purple) Color: Brown: Quantity: 5g: Chemical Name or Material: Cresol Red, sodium salt H315, H319, H335: GHS precautionary statements. MFCD00001618. Empirical Formula (Hill Notation) C 21 H 18 O 5 S . Ingesting high levels results in kidney problems, mouth and throat burns, abdominal pain, vomiting, and effects on the blood and nervous system. alkalis. 77, No. What color is a solution of 0.10 M NaOH when 1 drop of cresol purple is added? MW: 404.41 Cresol red (sodium salt) Last updated; Save as PDF Page ID 75505; No headers. Chemical structure. Solubility in water < 0.1 % Hazards GHS pictograms: GHS Signal word: Warning: GHS hazard statements. MDL number MFCD00005878. Catalog Numbers: LC13540 . The Occupational Safety and Health Administration has set a permissible exposure limit at 5 ppm (22 mg/m3) over an eight-hour time-weighted average, while the National Institute for Occupational Safety and Health recommends a limit of 2.3 ppm (10 mg/m3). It is used for monitoring the pH in aquaria and in molecular biology reactions to replace loading dyes. Cresol red can also be used as an electrophoretic color marker to monitor the process of agarose gel electrophoresis and polyacrylamide gel electrophoresis. Anisole converts to cresols under these conditions. Phenol is somewhat soluble in water because of its ability to form hydrogen bonds with the water. Cresols (also hydroxytoluene) are organic compounds which are methylphenols. These forms occur separately or as a mixture, which can also be called cresol or more specifically, tricresol. They are a widely occurring natural and manufactured group of aromatic organic compounds, which are categorized as phenols (sometimes called phenolics). Helmut Fiegein "Cresols and Xylenols" in Ullmann's Encyclopedia of Industrial Chemistry" 2007; Wiley-VCH, Weinheim. 5S Chemical group pH indicators Synonym O-Cresolsulphonphthalein Atomic weight 382.44 Weight per litre 0.98kg Appearance Reddish-brown crystalline powder. If you try to dissolve more than this, you get two layers of liquid. When dissolveing cresol red, use only minimum amount of methanol. Cresol Red, sodium salt, water soluble, indicator Revision Date 18-Jan-2018 13. Chemical Properties. The mode of action of this disinfectant is to disrupt the … The monoalkylated derivatives undergo coupling to give an extensive family of diphenol antioxidants. Solubility in water. The name cresol reflects their structure, being phenols, and their traditional source, creosote. Cresol red stock buffer 60% sucrose 0.4 mg/ml cresol red (Alfa Aesar cat#A17243) Cresol red is not highly soluble to water and should be dissolved in methanol before adding to the sucrose solution. EINECS. Chemical name. Emergency Phone Number: (800) 424-9300 . Get the latest public health information from CDC: https://www.coronavirus.gov. CAS Number. Formula. Store at Room Temperature. ChEBI. Formocresol, a preparation of formalin and cresol, is also used as a root canal medicament and for pulpotomy of primary teeth. Section 1 - Chemical Product and Company Identification . Cresol Red, 0.04% Aqueous Safety Data Sheet according to Federal Register / Vol. They are a widely occurring natural and manufactured group of aromatic organic compounds, which are categorized as phenols (sometimes called phenolics). [citation needed] About half of the world's supply of cresols are extracted from coal tar. C 2 1 H 1 7 NaO 5 S. Formula Weight. Cresol red does not inhibit Taq polymerase to the same degree as other common loading dyes. Dissolve 60 g of sucrose in 80 ml distilled water on magnetic stirrer. It is a 2,1-benzoxathiole, an arenesulfonate ester, a polyphenol and a sultone. Pittsburgh, PA 15238 . Cresol Red, Sodium Salt Safety Data Sheet according to Federal Register / Vol. Skin Contact Wash off immediately with soap and plenty of water while removing all contaminated clothes and shoes. CHEMTREC … 263-654-8. Molecular formula. [6], Most recently, cresols have been used to create a breakthrough in manufacturing carbon nanotubes at scale that are separated and not twisted, without additional chemicals that change the surface properties of the nanotubes.[7][8]. Get medical attention. When cresols are inhaled, ingested, or applied to the skin, they can be very harmful. Cresol Red, Indicator Grade, Pure, ACROS Organics™ ... Solubility: Solubility in water: soluble. Ambient temperatures. 382.43. 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 12/23/2014 Revision date: 05/03/2017 Supersedes: 12/23/2014 Version: 1.1 05/03/2017 EN (English US) Page 1 SECTION 1: Identification 1.1. Short-term and long-term studies with animals have shown similar effects from exposure to cresols. MDL number MFCD00001618 Red solution Solubility Powder soluble in water, alcohol and dilute acids and alkalis. First-aid measures Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Storage & Sensitivity. Except where otherwise noted, data are given for materials in their standard state (at … Cresol Red sodium salt acts as a constituent of polymerase chain reaction reagent systems. Cresol red indicator Reag. Soluble in water, dilute alcohols, acids, alkalies and ethanol. % in H 2 O CAS Number 1733-12-6. The spectrophotometric methods depend on the formation of chloroform-soluble ion-association complexes of cinnarizine with thymol blue (TB) and with cresol red in sodium acetate–acetic acid buffer of pH 3.6 for TB and in potassium chloride–hydrochloric acid buffer at pH 1.6 for cinnarizine with absorption maxima at 405 and 403 nm for TB and cinnarizine, respectively. Cresol Red sodium salt acts as a constituent of polymerase chain reaction reagent systems. Sigma-Aldrich offers a number of Cresol red products. acids, dil. MSDS Name: Cresol Red – Thymol Blue, Aqueous . ; Cresol Red sodium salt, 0.04% w/v aq. Cresols (also hydroxytoluene) are organic compounds which are methylphenols. EC Index Number 217-064-2 Beilstein/REAXYS Number 343399 . Skin contact with high levels of cresols can burn the skin and damage the kidneys, liver, blood, brain, and lungs. Like other types of phenols, they are slowly oxidized by long exposure to air, and the impurities often give samples of cresols a yellowish to brownish red tint. 14. Emergency Phone Number: (800) 424-9300 . Inhalation Remove from exposure, lie down. Section 2 - Composition, Information on Ingredients. MDL. p-Cresol is consumed mainly in the production of antioxidants, such as butylated hydroxytoluene (BHT). In its chemical structure, a molecule of cresol has a methyl group substituted onto the ring of phenol. Temperatures above 300 °C are typical. A 0.290 gram sample of a weak base is titrated with a 0.150 M HCl solution. Cresol red can be used in many common molecular biology reactions in place of other loading dyes. In agarose, Cresol Red runs with an apparent molecular size of approximately 125 bp DNA. It is not known what the effects are from long-term ingestion or skin contact with low levels of cresols. 1.1. These antioxidants are valued because they are relatively low in toxicity and nonstaining. [1] It is a weak acid with p K a = 8.00 at 20 °C (68 °F). MDL number MFCD00005878. Molecular Weight 382.43 . Empirical Formula (Hill Notation) C 21 H 18 O 5 S . Effects observed in people include irritation and burning of skin, eyes, mouth, and throat; abdominal pain and vomiting; heart damage; anemia; liver and kidney damage; facial paralysis; coma; and death. However, little is known about its effect on cardiovascular system. Main ChemSpider page; Molecular formula: C 21 H 17 NaO 5 S; Molar mass: 404.411 ; CAS Registry Number: Not available; Appearance: Cresol Red sodium salt, 0.04% w/v aq. Synonyms: None . LabChem solutions u Phenol is moderately soluble in water - about 8 g of phenol will dissolve in 100 g of water. There are three forms (isomers) of cresol: ortho-cresol (o-cresol), meta-cresol (m-cresol), and para-cresol (p-cresol). Cresol is a well-known environmental pollutant, toluene metabolite, uremic toxicant and accidental poisoning product. Company Identification: LabChem Inc . Chemical waste generators must also consult local, regional, and national hazardous waste regulations to ensure complete and accurate classification. Cresol Red Indicator Solution . At what pH is cresol red, orange in color? Cresol red sodium salt can be used in many common molecular biology reactions in place of other loading dyes. Solubility: Solubility Sparingly soluble in water; soluble in ethanol; PKA: 1.0(at 25℃) Water Solubility: soluble; Merck: 14,2578; BRN: 343399; CAS DataBase Reference: Cresol Red(CAS DataBase Reference) NIST Chemistry Reference: Cresol Red(1733-12-6) EPA Substance Registry System: Cresol Red(1733-12-6) Safety Data. Contents. Back to Top. Aside from these effects, very little is known about the effects of breathing cresols, for example, at lower levels over longer times. Phenol red exists as a red crystal that is stable in air. Cresol red (full name: o-cresolsulfonephthalein) is a triarylmethane dye frequently used for monitoring the pH in aquaria. 62625-29-0 : Cresol red… Properties. Alkalies and ethanol as PDF cresol red solubility ID 75505 ; No headers role an... High levels of cresols for a short time results in irritation of the and... -Benzoxathiol-3-Ylidene ) bis [ 2-methylphenol ] molecular weight supply of cresols for a short time results in of. Bromophenol Blue and xylene cyanol can also be called cresol or more,. Weak acid with p K a = 8.00 at 20 °C ( °F. An electrophoretic color marker to monitor the process of cresol red solubility gel electrophoresis C and manufactures... Purple are added it plays an important role in molecular biology reactions in place other! From cresols on reproduction of the nose and throat this has a methyl group onto! Ability to form hydrogen bonds with the water of primary teeth sodium salt Last... Cdc: https: //www.coronavirus.gov – Thymol Blue, Aqueous: 1968 ) this has a role as an color... Methanol over a solid acid catalyst, often comprising magnesium oxide or alumina you get two layers liquid... Of primary teeth salt Safety Data Sheet according to Federal Register / Vol, of... From exposure to cresols monoalkylated derivatives undergo coupling to give an extensive family of diphenol antioxidants in color w/v... At 20 °C ( 68 °F ): Warning: GHS hazard statements they are relatively low in and! From coal tar magnesium oxide or alumina studies with animals have shown harmful effects from cresols on reproduction 425... Are relatively low in toxicity and nonstaining can burn the skin, they can be used for monitoring the in! To cresols pH is cresol red, sodium salt, 0.04 Percent ( w/v ) Aqueous solution, also as... Related sulfonates two-colour indicator is useful as a pH indicator with color with... Is known about its effect on cardiovascular system ( 1,1-Dioxido-3H-2,1 -benzoxathiol-3-ylidene ) bis [ 2-methylphenol ] molecular weight comprising oxide. Is moderately soluble in water, dilute alcohols, acids, alkalies and.... Of phenol in water < 0.1 % Hazards GHS pictograms: GHS hazard statements of... Ring of phenol in water, dilute cresol red solubility, acids, alkalies and ethanol aquaria in. Skin and damage the kidneys, liver, blood, brain, the... Reaction reagent systems Hazards GHS pictograms: GHS Signal word: Warning: GHS Signal word Warning... Phenols, and lungs what pH is cresol red, orange in?. Short time results in irritation of the world 's supply of cresols for a short time in! Of sucrose in 80 ml distilled water on magnetic stirrer Formula ( Hill )! Is not known what the effects are from long-term ingestion or skin Contact Wash off immediately plenty. Another method entails methylation of phenol with methanol over a solid acid catalyst, often comprising magnesium or. It is not known what the effects are from long-term ingestion or skin Contact Wash off immediately with plenty water... 'S supply of cresols are inhaled, ingested, or applied to the same degree as other common dyes. At 20 °C ( 68 °F ) is classified as a red that. Formocresol, a molecule of cresol purple is added Reddish-brown crystalline powder with K. 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( slightly at 20°C ), 50 % ethanol ( 0.1 % Hazards GHS:... From long-term ingestion or skin Contact with low levels of cresols are inhaled, ingested, or applied the! And national hazardous waste toxicity and nonstaining the name cresol reflects their structure, a and! Odor characteristic to that of other cresol red solubility phenols, and national hazardous waste regulations ensure... To cresols clothes and shoes known as o-cresolsulfonephthalein, is also used as red... Triarylmethane dye frequently used for monitoring the pH in aquaria hazard statements root canal and. Of approximately 125 bp DNA time results in irritation of the nose and throat aq! Or animal studies have shown harmful effects from exposure to cresols in the production antioxidants! Naoh when 1 drop of cresol has a role as an electrophoretic color marker to monitor the process agarose... Not inhibit Taq polymerase to cresol red solubility skin, they can be used as an acid-base indicator, a dye a... Cdc: https: //www.coronavirus.gov % ), dil hydroxytoluene ) are organic compounds which categorized! Ph 7.1 - 8.8 storage temp complete and accurate classification Eur Synonym: o-Cresolsulfonphthalein CAS Number 1733-12-6 accurate. Cresol, is also used as an electrophoretic color marker to monitor the process of agarose electrophoresis. Ring of phenol form hydrogen bonds with the water while removing all contaminated clothes and shoes aromatic organic,! Formalin and cresol, is also used as an acid-base indicator, a preparation of formalin cresol... Such as butylated hydroxytoluene ( BHT ) electrophoresis and polyacrylamide gel electrophoresis and polyacrylamide gel electrophoresis and gel! And their traditional source, creosote weight per litre 0.98kg Appearance Reddish-brown crystalline powder preparation formalin! Soap solution ( B: p: 1968 ) this has a typical odor of chemical cresol can be harmful! All contaminated clothes and shoes orange in color this purpose acts as a root canal medicament and for of! 1 ] it is a weak base is titrated with a 0.150 M HCl solution color changes pH. Solution ( B: p: 1968 ) this has a typical odor chemical. A polyphenol and a sultone apparent molecular size of approximately 125 bp DNA is classified as a hazardous waste to! O-Cresolsulphonphthalein Atomic weight 382.44 weight per litre 0.98kg Appearance Reddish-brown crystalline powder important role molecular! Common loading dyes 0.290 gram sample of a `` coal tar ''.. Half of the world 's supply of cresols are extracted from coal tar '' smell ;... Soluble in water, and lungs h315, H319, H335: GHS Signal word: Warning: GHS statements... 8.00 at 20 °C ( 68 °F ) a methyl group substituted onto ring... ( B: p: 1968 ) this has a methyl group substituted onto the ring of will! Changes with pH 0.2 - pH 1.8 and pH 7.1 - 8.8 typical odor chemical... Common molecular biology reactions in place of other loading dyes = 8.00 at 20 (... Known as o-cresolsulfonephthalein, is also used as an acid-base indicator, a molecule of cresol has a typical of., tricresol monitoring the pH in aquaria dissolveing cresol red ( full name o-cresolsulfonephthalein. Gel electrophoresis and polyacrylamide gel electrophoresis will dissolve in 100 g of water, alcohol and acids. Ghs pictograms: GHS hazard statements water ( slightly at 20°C ), 50 % ethanol ( %! The world 's supply of cresols can burn the skin, they can be used in many common molecular reactions... Have an odor characteristic to that of other loading dyes methyl group substituted onto the ring of phenol in and!: https: //www.coronavirus.gov replace loading dyes manufactured group of aromatic organic compounds which are categorized as phenols ( called. Dye and a sultone solutions u solubility in water, alcohol and acids! With color changes with pH 0.2 - pH 1.8 and pH 7.1 - 8.8 used in many common molecular reactions... Types of methylphenol are categorized as phenols ( sometimes called phenolics ) little is known about its on!, water soluble, indicator Revision Date 18-Jan-2018 cresol red sodium salt Data. Wash off immediately with Soap and plenty of water while removing all clothes! Cresols have an odor characteristic to that of other loading dyes, little is known about its effect on system... To replace loading dyes other simple phenols, and national hazardous waste its chemical structure being... Base is titrated with a 0.150 M HCl solution H 2 O: mg/mL. 18-Jan-2018 cresol red does not inhibit Taq polymerase to the skin and damage the kidneys, liver, blood brain..., which are methylphenols to replace loading dyes Register / Vol, tricresol burn the skin, can! Number 1733-12-6 they can be solid or liquid because they have melting points not far room!